Open Synthesis Network Research in an Undergraduate Laboratory: Development of Benzoxazole Amide Derivatives against <i>Leishmania</i> Parasite
نویسندگان
چکیده
An undergraduate laboratory was developed as part of the Drugs for Neglected Diseases initiative’s Open Synthesis Network. This activity aimed to develop new compounds efficacious against visceral leishmaniasis. Students successfully synthesized, purified, and characterized ten different benzoxazole amides that were sent biological testing several protozoan parasites. Although all had poor L. donovani, (2, 4, 9) showed moderate T. cruzi, b. rhodesiense, brucei paired with low cell cytotoxicity. drug discovery made a measurable contribution neglected tropical disease research an engaging research-orientated experience students. Implementation laboratories across range student levels backgrounds is highly achievable using existing equipment short investment in preparation can be sustainable course component.
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ژورنال
عنوان ژورنال: Journal of Chemical Education
سال: 2022
ISSN: ['0021-9584', '1938-1328']
DOI: https://doi.org/10.1021/acs.jchemed.1c01213